Prazotec Injection Special Precautions

As Prazotec Injection 30 mg was shown to have high hemostatic effect based on the data up to 3 days after starting treatment, once the patient is able to take medications orally. Therapy should be switched to an oral formulation and this drug should not be administered aimlessly for a long period.
There is no clinical experience of treatment over 7 days in Japanese clinical trials.
Careful Administration: Prazotec Injection 30 mg should be administered with care in the following patients: Patients with a history of drug hypersensitivity.
Patients with hepatic disorders. (A delay in the metabolism and excretion of Prazotec Injection 30 mg may occur).
Elderly patients (see Use in Elderly as follows).
Important Precautions: At the treatment, the course of the disease should be closely observed and the minimum therapeutic necessity should be used according to the disease condition. If Prazotec Injection 30 mg is ineffective, it should be switched to another treatment.
If the patient has projectile bleeding or oozing bleeding, or is considered at risk for rapid bleeding such as the case of presence of exposed blood vessels, the patient should undergo endoscopic hemostasis such as heater probe or clipping.
Precautions for coadministration: Prazotec Injection 30 mg should be administered with care when coadministered with the following drugs: See Table 2.


Click on icon to see table/diagram/image


Other Precautions: It has been reported from abroad that visual disturbance occurred with use of a similar drug (omeprazole).
The administration of Prazotec Injection 30 mg may mask the symptoms of gastric cancer. It is, therefore, necessary to ascertain the ulcer is not of a malignant nature before initiating the administration of this drug.
Use in Children: The safety of Prazotec Injection 30 mg in children has not been established (no clinical experience).
Use in Elderly: Since physiological function generally decreased in elderly patients, Prazotec Injection 30 mg should be carefully administered.